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Investigational Blinatumomab Puts BiTE on Acute Lymphoblastic Leukemia

February 2012 Vol 5, No 1, Special Issue - Leukemia

The novel agent blinatumomab more than doubled the complete response (CR) rate in adult patients with relapsed or refractory B-precursor acute lymphoblastic leukemia (ALL) compared with standard therapies. If validated, these findings offer significant hope to patients with an otherwise dismal prognosis after having failed to achieve CR with standard treatment.

Blinatumomab is a member of the BiTE (bispecific T-cell engager) drug class, a bispecific monoclonal antibody designed to direct the cytotoxic T-cells of the host’s immune system, via CD3, to attack CD19-expressing cancer cells.

In this open-label, single-arm, dose-ranging, phase 2 clinical trial, 25 patients with ALL were randomized to 1 of 3 doses of blinatumomab. Results for all tested doses showed that  17 (68%) of the patients achieved a CR or a CR with partial hematologic recovery with blinatumomab.

For the 12 patients who received the dose selected for further investigation, 9 achieved a CR or partial hematologic recovery. All responders achieved minimal residual disease status, meaning that there were no detectable leukemic cells in their blood or bone marrow.

Treatment effect with blinatu­m­omab was lasting, with a median complete hematologic remission of 7.1 months. At a median follow-up of 9.7 months, median survival time has not been reached. This ongoing measure already exceeds median survival times typically seen with combination chemotherapy in ALL.

The most common adverse events observed with initial blinatumomab treatment were mild, and were predominantly flulike symptoms of fever and headache.

More serious, but reversible, events included cytokine release syndrome in 2 patients with high tumor burden, and 5 patients with central nervous system events (3 with seizures and 2 with disorientation). Events for all 7 patients were managed with treatment interruption, and all 7 continued the trial after event resolution. There were no treatment-related deaths.   

“Blinatumomab as a single agent induced an unprecedented high rate of complete hematological and minimal residual disease responses in adult patients with relapsed/refractory B-precursor ALL,” said the study’s lead investigator, Max S. Topp, MD, at Wuerzburg University Medical Center, Wuerzburg, Germany, where phase 2 studies are under way.—NC
 

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Last modified: August 30, 2021